The key in determining coin values is to first decide if the coin HAS any value as a type, then if it has value over type. What is a common coin of that type in that grade worth. Is this worth more because of the date and mint mark?
If either of those is significant, than you have a coin worth doing more research on (for example, if you have a 1964 Washington quarter in very good condition, it is not worth much more than silver value, while a 1932s in the same grade will have significant extra value. In the same vein, an 1881 s morgan dollar has some value, while an 1887 s is worth significantly more and worth a closer look).
There once you know IF a coin has significant value over type or is of a valuable type, then you can decide to move forward (you do not want to spend time looking up the value of a bunch of 1950's lincoln pennies since none of them (save the double die) have significant value over type (sure, worth $.15 instead of $.05).
What you need to do is go through the coins with an eye toward eliminating from closer inspection and research those that do not have significant value. In this way, you can spend your time most efficiently. You can then move coins into categories such as spenders (no value, spend them), metal value (late date silver), Type coins, and rare coins.