We had another thread going about Lake Mead but the mods had to shut it down when the discussion got political. I reviewed on Wikipedia the Tennessee Valley Authority (TVA) project that began in 1933 and how it evolved over the last 90 years. A great example of how a successful project can be a success beyond original expectations.
I wonder if a group of colleges, now using computer simulations could build a model of water reclamation from the Midwest (Mississippi River area) westward to Lake Mead.
Three colleges come to mind as a start: University of Missouri, University of Colorado (School of Mines) and the University of Nevada. They could add other schools as necessary and try to take in to account all necessary considerations such as environmental, engineering, etc.
Read the TVA story it's about 10 pages and it makes a great case study. The colleges could make this a great school project.