Being realistic and going with something you can get your hands on, lets assume you have a modern detector and not one of the relics mentioned.
A smaller coil will help, but if you want to get a search going and use the stock coil then turn your DISC to a level below nickels that strikes a happy medium. An old house site that actually goes that far back
and actually has stuff to find
and hasnt been hunted before will yield targets in the mid range, like nice buttons. So you dont want to DISC too much. Yes, you will have to accept nails and other iron trash as part of the bargain - iron has been the friend of man since its discovery and it has been used for everything. EVERYTHING. But, all is not lost. Read on.
Now comes the hard part. Take a GIANT shovel ful of patience and STOP expecting your detector to work miracles. Instead, try learning about the nails: what they are and how they actually respond. Old nails are distinctive and can help add to your knowledge of the site, at the very least. However, more than that, trash repeaters like nails always have a revealing signature that patience will reveal. They are also sure indicators that you are in the right
area. They pretty well establish the precise site of a house. So dont despair!
Okay, now comes the good part. Start moving
off a ways and working your way around the site, grid by grid. You really are forced to be an archeologist in a case like this, so adopt their methods. Odds are you WILL NOT find the good stuff right away - it takes time and patience. Add to this that right on top of where an old house stood is not going to be as good as the areas outbound from the house where people actually DID stuff, with a few exceptions. Its the same way at your house, aint it? So "re-construct" the old place.
Where was the front and rear of the house? how wide was it? Where would the laundry lines and washing area be, the outside cooking area, the outside sitting area and garden? How about the outhouse and where did the wagons pull up and where were the horses wrangled. Where were the outbuildings, the sheds, the "swing" tree, the root cellars and so on? How about the paths between all these?
Now, the corners of the house where the footing piers stood can produce a money cache, as people liked to stash such there. Wherever the front porch was (if there was one) can pay off, too. Ditto a cellar hole. Forgotton caches will also have come down with the house, if there were any. Otherwise the house itself sat on top of, well, nothing, and there is less to find there, even if there was a dirt floor. Work in first and save the all the nails for last.