Wrist/arm/shoulder fatigue -- or even pain -- is something that I know several folks deal with, with the Equinox. It's one of the machine's few (in my opinion) shortcomings -- too much weight at one end (the coil end), and nearly ZERO at the other (butt) end. Thus, it's an unbalanced machine, forcing you to exert the necessary force with your wrist/arm/shoulder to counteract that nose-heaviness.
Along with the other ideas mentioned in this thread which can help reduce the issue, another thing that helps with the nose-heaviness, and resulting ergonomic issues, is to run your lower rod a bit shorter than you otherwise might. Having the coil in closer to your feet (i.e. the machine in a bit more "vertical" position), while you swing, reduces the "leverage effect" of the coil. Think of how much harder it is to hold the detector out in front of you, parallel to the ground. Try that -- sort of in a "shooting from the hip" position, and see how heavy the machine feels, and how difficult it becomes, in a short period of time, to hold the machine level/parallel to the ground. From that perspective, the more "upright" you swing your machine, the "lighter" it feels, and the easier it is on your "swinging arm" (as would be expected from a leverage/physics perspective).
If all of these options mentioned here don't help, the other very good (in my biased opinion, LOL) option is COUNTERWEIGHTING. Using counterweighting really does help. You can rig something up to counterweight the machine in a DIY manner, OR -- I offer that option (a nice, carbon-fiber, removable and adjustable counterweight) with my carbon-fiber shafts...
Steve