Yes, some pre 1960 nickels can be sold on eBay for a nice profit if you are willing to do that. For me though, unless it is a key date, war nickel or pre-Jefferson nickel, I won't bother saving it. All nickels from the first ones made in 1866 to today have been made out of 25% nickel and 75% copper, with the exception of the 1942-1945 war nickels that are 35% silver.
There are some people who hoard nickels in preparation for the collapse of the dollar, but since no one is paying any premium for nickels, and the composition hasn't been changed in over one hundred years, most are waiting for a change in composition to stock up on nickels since most banks have a few boxes available for anyone who wants them.
Some people enjoy doing nickels and have had good luck with them, I personally haven't, but a lot of people have reported seeing a lot of foreign coins, about 1-2 war nickels per box, and many people have reported finding buffaloes, "V" nickels and I've even seen a shield nickel found in this forum!